Buerger´s disease or Thromboangiitis obliterans is a segmental inflammatory disease . One hundred years after the original description by Leo Buerger, the aetiology of the disease remains unknown. . Maladie de Buerger. Buerger’s disease or thromboangiitis obliterans is an inflammatory, segmental and révélatrice d’une thromboangéite oblitérante ou maladie de Léo-Buerger. Confusion possible entre maladie de Buerger et maladie de Hansen en milieu tropical La maladie de Buerger ou thromboangéte oblitérante . Leo Buerger.

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Selective cannabinoid receptor antagonists, such as rimonabant, which shows promise as a treatment for helping patients to stop smoking, open up interesting new treatment perspectives for this disease strongly related to tobacco use [ 8990 ].

The study for thrombophilia and immunology was negative table 1. These cases might beurger triggered by cold, frostbite, traumatism of the extremities or even abuse of sympathomimetic drugs [ 3720—22 ]. A report of three cases.

Maladie de Leo-Buerger faisant suite а une intoxication au cannabis

Arteriovenous fistula Arteriovenous malformation Telangiectasia Hereditary hemorrhagic telangiectasia. Measurement of toe systolic pressure and of transcutaneous oxygen pressure can be used to confirm the ankle—toe gradient and the severity of ischaemia. TAO remains a systemic vasculitis strangely linked to smoking, which determines its occurrence, progression and prognosis by currently unknown mechanisms.

Implantable spinal cord stimulator to treat the ischemic manifestations of thromboangiitis obliterans Buerger’s disease. Curr Opin Rheumatol ; U8 literatur 25 antoni dh, luderitz b hochschmerzhafte akrale nekrosenbildung in jugendlichem. Impaired endothelium-dependent vasorelaxation in peripheral vasculature of patients with thromboangiitis obliterans Buerger’s disease.

The aim is to obtain cleansing of the wound with the creation of sufficient new tissue to enable healing. An eponymous disease is a disease named after a person. The cause of the disease is thought to be autoimmune in nature and heavily buergsr to tobacco use in patients with Buerger’s as primary disease.


The intensity of this pain often contrasts with the apparently limited, almost benign appearance of buerge ischaemic trophic lesions Fig. The appearance of panvasculitis described by Buerger [ 15 ], in which inflammatory infiltrate extends to all the layers of the vessel wall without mutilation, is rarely observed in the arteries. Another preliminary report in four patients with TAO has recently suggested that stem cell therapy using umbilical cord blood-derived multipotent stem cells may be useful in healing the necrotic skin lesions and relieving pain [ ].

J Rheumatol ; In chronic cases, lumbar sympathectomy may be occasionally helpful. Five of seven patients showed an increase in collateral vessels dde the injection sites.

Rev Med Interne ; In addition to these variable and non-specific pathological findings, TAO can be distinguished from other types of vasculitis based on its tendency to occur in young male subjects, its close association with tobacco consumption, the rarity of systemic signs and symptoms, a highly cellular thrombus with relative sparing of the blood vessel wall, the absence of elevated acute-phase reactants and of immunological markers.

The diagnosis and treatment of this entity is challenging, since it requires the exclusion of many other causes and a multidisciplinary approach. Inflammation Arteritis Aortitis Buerger’s disease. The nailfold capillaroscopy was suggestive of systemic vascular disease, with active capillaritis. It affects the small and medium-sized arteries and veins of the limbs. He was submitted to disarticulation of the second left toe and therapy with pentoxifyline and iloprost infusion, calcium antagonist, antiplatelet drugs, statin and low molecular weight lso later replaced by oral anticoagulation.

Stem Cells ; New aspects of thromboangiitis obliterans von Winiwarter-Buerger’s disease.

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Open in a separate window. Intestinal involvement is rare in cases of TAO [ 50—59 ]. The small and medium-sized arteries are affected in a segmental and often bilateral manner. An impaired endothelium-dependent vasorelaxation in the peripheral vasculature, even in the non-diseased limbs, has been shown in patients with TAO [ 26 ]. Published online Sep Buerger Disease Tromboangiitis Obliterans. Treatment of thromboangiitis obliterans Buerger’s disease by intramuscular gene transfer of vascular endothelial growth factor: The commonly followed diagnostic criteria are outlined below although the criteria tend to differ slightly from author to author.


Fiessinger JN, Schafer M. Buerger’s disease in the modern era. The clinical criteria for TAO, edited by Olin in include: For example, prostaglandins like Limaprost [10] are vasodilators and give relief of pain, but do not help in changing the course of disease.

N Engl J Med. It usually affects men below 45 years old and correlates with tobacco, as a predisposing factor. Searches for rheumatoid factor, anti-nuclear antibodies, anti-centromere antibodies, anti-SCL antibodies and ANCA are necessary, but should be negative, as should tests for hypocomplementaemia, cryoglobulinaemia, hepatitis B and C. A study of the vascular lesions leading to presenile spontaneous gangrene.

Chronic venous insufficiency Chronic cerebrospinal venous insufficiency Superior vena cava syndrome Inferior vena cava syndrome Venous ulcer. A year-old black male presented in the medicine clinics with a 6 year history of ulcers in the fingertips of both hands and feet with progressive worsening: The author and journalist John McBeth describes his experiences of the disease, and treatment for it, in a chapter called ‘Year of the Leg’ in his book entitled Reporter.

TAO usually begins with ischemia of the distal small arteries and veins.