Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.

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Histone demethylation by a family of JmjC domain-containing proteins.

Missing in isoform b. Transcription jmjc-domaib-containing, Transcription regulation. These proteins belong to the JmjC-domain-only subgroup and as their name suggests, the only bioinformatically recognizable domain they contain is the highly conserved JmjC domain. KershawNicolas GranatinoChristopher J. Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain was later found without the JmjN domain in organisms from bacteria to human [ PMID: You have a close personal relationship e.


The N-termini “tails” of the histone proteins are subject to a diverse array of posttranslational modifications including methylation.

The algorithm is described in the ISO standard. JmjC domain-containing histone deme Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution. Covalent modification of histones has an important role in regulating chromatin dynamics and transcription.

JmjC-domain-containing proteins and histone demethylation.

Contributing signatures Signatures from InterPro member databases are used to construct an entry. Impaired mitochondrial energy metabolism in Alzheimer’s disease: Histones are evolutionarily conserved proteins intimately involved in the packaging of DNA within the nucleus of eukaryotic organisms. These are stable identifiers and should be used to cite UniProtKB entries. Please consider upgrading your browser.

Emerging Roles of JmjC Domain-Containing Proteins.

Bgee i WBGene Expressed in 5 organ shighest expression level in multi-cellular organism. ProtoNet; Automatic hierarchical classification of proteins More Structural insights into histone demethylation by Jmjc-romain-containing family members.


From This Paper Figures, tables, and topics from this paper. Four distinct tokens exist: Eukaryotic Ortholog Groups More These terms shall be governed by and construed in accordance with English Law.

JmjC domain (IPR) < InterPro < EMBL-EBI

It is useful for tracking sequence updates. You are an Editor for the journal in which the article is published.

Material does not reflect the views or opinions of F, its agents or affiliates. Chromatin regulatorDioxygenaseOxidoreductase. I am a Faculty Member who recommended this article.